John Humphries has been President and General Manager of WYFF 4 since July 2016. Prior to his return to the Upstate of South Carolina, Humphries held the same position from 2012-2016 at Hearst Television sister station, WGAL-TV, the NBC affiliate serving the Lancaster-Harrisburg-Lebanon-York, Pennsylvania television market. Prior to WGAL, Humphries oversaw sales for WYFF-TV, WYFF4.com, WYFF 4 Mobile and the digital multicast channel MeTV Carolina. He holds a bachelor’s degree in Speech from Appalachian State University, in Boone, NC, for which he has served on the Alumni Council.

Under his stewardship the Associated Press of South Carolina named WYFF 4 Outstanding News Operation in 2017. The station was also honored with a Southeast Regional Emmy for Outstanding Newscast in 2018. The South Carolina Association of Broadcasters recognized WYFF 4 as their Station of the Year in 2021. In 2022 WYFF News 4 was awarded a prestigious national Edward R. Murrow Award. In 2018 Humphries was named General Manager of the Year for mid-size television markets by national publication Broadcasting & Cable.

Among Humphries' industry associations, he is immediate past president of the board of the South Carolina Broadcasters Association and currently president of the SCBA Educational Foundation. He has served on the Television Bureau of Advertising (TVB) Sales Advisory Committee. Among his civic and charitable associations, he has served on the board for United Way of Greenville County, and currently serves on the boards of the Greenville Chamber of Commerce, the South Carolina Chapter of the Cystic Fibrosis Foundation, and the Urban League of the Upstate. He is recognized by The Riley Institute at Furman University as a Riley Institute Diversity Fellow.