Education

Ph.D.  Biochemistry (Molecular Immunology and Signal Transduction), National University Autonomous of Mexico, 2019
M.Sc.  Biochemistry (Molecular Immunology and Signal Transduction), National University Autonomous of Mexico, 2014
B.Sc.  Biology, National University Autonomous of Mexico, 2009

Background

Jorge Ivan Castillo Arellano, Ph.D., has an extensive background in multiple biological disciplines including immunology, molecular biology, biochemistry, and phytochemistry. As an undergraduate, he conducted research on biosynthesis of natural products known as calanolides (dypirancoumarins) with HIV-RT and Mycobacterium tuberculosis inhibitor activity. As a master and Ph.D. student, his research focused on the role of Fyn kinase on TLR4 receptor pathway in mast cells and the potential of natural products with anti-allergy and anti-inflammatory activity thought of inhibition of degranulation of mast cells. 

Dr. Castillo Arellano has expertise in Immunofluorescence microscopy; Fluorometrical analysis; RT-PCR; Western Blot; Electrophoretic Mobility Assays (EMSA); Gel Electrophoresis; Cell culture; Isolation of natural compounds; HPLC; 1H and 13C-NMR interpretation; Mass Spectrometry interpretation; Mice Handling; Testing in vivo of anti-inflammatory activity of pharmacological compounds with passive cutaneous anaphylaxis model and TPA-induced edema model in mice ear; Field work and plant growing; Patent analysis and writing. 

Research Interests

• Signal transduction in T cells, macrophages, mast cells and others immune cells
• Isolation of novel natural products with immunomodulatory activity
• Development of peptides with immunoregulatory activity

Publications

Patent application MX/a/2019/027589. Natural inhibitors of inflammation and allergy. Inventors: Jorge Ivan Castillo Arellano, Ricardo Reyes Chilpa and Claudia González Espinosa. Applicants: Universidad Nacional Autónoma de México and Centro de Investigación y de Estudios Avanzados del IPN. Date of application: 30/04/2019.

Ramírez-Moreno, I. G., Ibarra-Sánchez, A., Castillo-Arellano, J. I., Blank, U., & González-Espinosa, C. (2020). Mast Cells Localize in Hypoxic Zones of Tumors and Secrete CCL-2 under Hypoxia through Activation of L-Type Calcium Channels. The Journal of Immunology; 204(4): 1056-1068. www.jimmunol.org/cgi/doi/10.4049/jimmunol.1801430 

Castillo-Arellano, J.I., Guzmán-Gutiérrez, S.L., Ibarra-Sánchez, A., Hernández-Ortega, S., Nieto-Camacho, A., Medina-Campos, O.N., Pedraza-Chaverri, J., Reyes-Chilpa, R., and González-Espinosa, C. (2018) Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells. Journal of Biochemical Pharmacology; 154:344-356. https://doi.org/10.1016/j.bcp.2018.05.002  

Castillo-Arellano, J.I., Gómez-Verjan, J.C., Rojano-Vilchis, N.A., Mendoza-Cruz, M., Jiménez-Estrada, M., López-Valdés, H.E., Martínez-Coria, H., Gutiérrez-Juárez, R., González-Espinosa, C., Reyes-Chilpa, R. and Arrieta-Cruz I. (2018) Chemoinformatic analysis of selected cacalolides from Psacalium decompositum and Psacalium peltatum and their effects on FcεRI dependent degranulation in mast cells. Molecules, 23(12), 3367. https://doi.org/10.3390/molecules23123367  

Castillo-Arellano, J.I., Osuna-Fernández, H.R., Mumbru-Massip, M., Gómez-Cancino, R. and Reyes-Chilpa, R. (2019). The biosynthesis of pharmacologically active compounds in Calophyllum brasiliense seedlings is influenced by calcium and potassium under hydroponic conditions. Botanical Sciences 97 (1): 89-99. DOI: 10.17129/botsci.2018.

Cruz, S. L. Sánchez-Miranda, E., Castillo-Arellano, J. I., Cervantes-Villagrana, R. D., Ibarra-Sánchez, A. and González-Espinosa, C. (2018) Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers. International Immunopharmacology; 64: 298-307 https://doi.org/10.1016/j.intimp.2018.09.006  

Guzmán-Gutiérrez, S. L., Nieto-Camacho, A., Castillo-Arellano, J. I., Huerta-Salazar, E., Hernández-Pasteur, G., Silva-Miranda, M., Argüello-Nájera O., Sepúlveda-Robles O., Inés Espitia C., and Reyes-Chilpa R. (2018). Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative. Molecules, 23(2), 334. doi:10.3390/molecules23020334 

Martín-Ávila, A., Medina-Tamayo, J., Ibarra-Sánchez, A., Vázquez-Victorio, G., Castillo-Arellano, J. I., Hernández-Mondragón, A. C., and González-Espinosa, C. (2016). Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion. The Journal of Immunology, 196(12), 5075-5088. https://doi.org/10.4049/jimmunol.1501823 

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