Background

Research Interests

• Biomaterials
• Nanoparticle Systems
• Drug Delivery
• Alzheimer’s Disease

Research Lab

The primary interests of Dr. Xu's lab are design and synthesis of biomaterials and exploring their biomedical applications. The long-term goals of the research are to develop cancer targeted nano-sized drug carrier to eradicate cancer and to design novel drug formulation to alleviate central nervous system diseases.

Awards & Honors

• Entrepreneurship, Leadership and Innovation Award, USC College of Pharmacy, 2022

Publications

He, H., Cattran, A., Nguyen, T., Nieminen, A., and Xu, P.* (2014) Triple-responsive Expansile Nanogel for Tumor and Mitochondria Targeted Photosensitizer Delivery. Biomaterials, (2014), 35, 9546–9553.

K.C., R. and Xu, P.* Multicompartment intracellular self-expanding nanogel for targeted delivery of drug cocktail. Advanced Materials (2012) 24(48): 6479-6483. Highlighted as a key scientific article in Global Medical Discovery, Reported by Science Daily, Drug Discovery Today, Azonano, Genesis Nanotech, and Newswise.

Xu, P., Li, S., Li, Q., Van Kirk, E.A, Ren, J., Murdoch, W.J., Zhang, Z., Radosz, M., and Shen, Y. Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angewandte Chemie-International Edition (2008) 47(7): 1260-1264.

Xu, P., Van, Kirk E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y. Targeted charge-reversal nanoparticles for nuclear drug delivery. Angewandte Chemie-International Edition (2007) 46(26): 4999-5002. (Highlighted http://www.nanowerk.com/spotlight/spotid=2113.php)

Xu, P., Van Kirk, Edward E.A., Murdoch, W.J., Zhan, Y., Isaak, Dale D., Radosz, M., and Shen, Y. Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules (2006) 7(3): 829-835. (Selected as one of the four “the Most Intriguing work” by CAS scientists for 2Q of 2006 from over 200,000 documents per quarter, including articles from nearly 9,500 journals, and patents from 50 active patent-issuing authorities from around the world).

Cheng, B., Thapa, B., K.C., R., and Xu, P.* Dual secured nano-melittin for safe and effective eradicating cancer cells. Journal of Materials Chemistry B (2015), 3 (1), 25 – 29.

K.C., R., Chandrashekaran, V., Cheng, B., Chen, H., Peña, M., Zhang, J., Montgomery, J., Xu, P.* Redox Potential Ultrasensitive Nanoparticle for Targeted Camptothecin Delivery to HER2-Positive Cancer Cells. Molecular Pharmaceutics, (2014), 11: 1897−1905.

Chen, Y., Wu, C., Yeo, Y., Xu, P., Lin, T. A DNA prime-protein boost vaccination strategy targeting turkey coronavirus spike protein fragment containing neutralizing epitope against infectious challenge. Veterinary Immunology and Immunopathology (2013) 152: 359– 369.

Cao, Z., Chen, F., Bao, N., He, H., Xu, P., Jane S., Jung S. and Lu C. Droplet sorting based on the number of encapsulated particles using a solenoid valve. Lab on a Chip (2013) 13(1): 171-8.

K.C., R., Thapa, B., and Xu, P.* pH and redox dual responsive nanoparticle for nuclear targeted drug delivery. Molecular Pharmaceutics (2012) 9(9): 2719-2729. (One of the journal’s Top 10 most read articles during July-September 2012)

K.C., R., Thapa, B., and Xu, P.* Design of serum compatible tetrary complexes for gene delivery, Macromolecular Bioscience. (2012) 12: 637–646. (Selected as journal cover)

Chen, F., Zhan, Y., Geng, T., Lian, H., Xu, P., and Lu, C. Chemical transfection of cells in picoliter aqueous droplets in fluorocarbon oil. Analytical Chemistry (2011) 83(22): 8816-20.

Xu, P., Bajaj, G., Shugg, T., Van Alstine, W., and Yeo, Y. Zwitterionic chitosan derivatives for pH-sensitive stealth coating. Biomacromolecules (2010) 11(9): 2352-2358.

Shen, Y., Zhou, Z., Sui, M., Tang, J., Xu, P., Van Kirk, E.A., Murdoch, W.J., Fan, M., and Radosz, M. Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery. Nanomedicine (2010) 5(8): 1205-17.

Ma, H., Jones, K.R., Guo, R., Xu, P., Shen, Y., and Ren, J. Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress. Clinical and Experimental Pharmacology and Physiology (2010) 37(4): 460-465.

Xu, P. Quick, G., and Yeo, Y. Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimine. Biomaterials (2009) 30(29): 5834-43.

Ma, H., Li, S., Xu, P., Babcock, S.A., Dolence, E.K., Brownlee, M., Li, J., and Ren, J. Advanced glycation end product (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy. Journal of Cellular and Molecular Medicine (2009) 13(8b): 1751-64.

Xu, P., Gullotti, E., Tong, L., Highley, C.B., Errabelli, D.R., Hasan, T., Cheng, J.,   Kohane, D.S., and Yeo, Y. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Molecular Pharmaceutics (2009) 6(1): 190-201.

Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M., and Yeo, Y. Development of highly porous large PLGA microparticles for sustained local drug delivery to the lung. Biomaterials (2009) 30(10): 1947-53.

Shen, Y., Zhan, Y., Tang J., Xu P., Johnson P.A., Radosz M., Van Kirk E.A., and Murdoch, W.J. Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE Journal (2008) 54 (11): 2979-2989.

Turdi, S., Xu, P., Li, Q., Kerram, P., Shen, Y., and Ren, J. Amidization of doxorubicin alleviates doxorubicin induced cardiomyopathy. Toxicology Letters (2008) 178(3): 197-201.

Jin, W., Xu, P., Zhan, Y., Shen, Y., Van Kirk, E.A., Alexander, B., Murdoch, W.J., Liu, L., and Issak, D.D. Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta-aminoester)-graft-PEG for cancer chemotherapy. Drug Delivery (2007) 14(5): 279-86.

Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y. Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotechnology & Bioengineering (2006) 95(5): 893-903.

Xu, P., Van Kirk, E.A., Li, S., Murdoch, W.J., Ren, J., Hussain, M.D., Radosz, M., and Shen, Y. Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces. (2006) 48(1): 50-57.

Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y. Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules (2004) 5(5): 1736-1744.

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