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- Hippokratis Kiaris
Faculty and Staff
Hippokratis Kiaris, Ph.D.
Title: | Professor Director, Center for Targeted Therapeutics; Director, Peromyscus Genetic Stock Center |
Department: | Drug Discovery & Biomedical Sciences (DDBS) College of Pharmacy |
Email: | kiarish@cop.sc.edu |
Phone: | 803-777-9322 |
Office: | College of Pharmacy 715 Sumter Street - CLS 713B Columbia, SC 2028 |
Education
Ph.D. Molecular Biology, University of Crete, 1997
B.S. Biology, University of Athens, 1993
Postdoctoral Fellowship
Cancer genetics, Harvard University, 2000-2003
Tumor Biology, Tulane University, 1998-2000
Research Interests
Context specificity and carcinogenesis
Our laboratory is interested on how context specificity affects the kinetic profile,
the morphology and the properties of malignant tumors. We are particularly intrigued
by the fact that the same type of cancer cells can develop into tumors of distinct
properties, metastatic activity and sensitivity to therapy depending on the microenvironment.
Based on this notion we believe that appropriate manipulation of tumor stroma may
provide the basis for the development of novel cancer therapeutics.
ER stress
Over the last few years we have developed an increasing interest in the role of endoplasmic
reticulum (ER) stress in various conditions and especially in diabetes. We are especially
interested to understand how ER stress progresses from its adaptive (pro-survival)
activity into its pro-apoptotic function. We believe that interference with the efficiency
by which ER stress becomes pro-apoptotic may have significant therapeutic implications.
Furthermore, it illuminates basic aspects of β cell biology with implications in a
variety of pathological conditions.
Research Topics
- microenvironment
- stroma
- breast cancer
- metastasis
- endoplasmic reticulum stress
Publications
Articles
Kiaris H. & Chatzistamou I., Tumor growth inhibition by agonists of growth hormone – releasing hormone. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):11876-11878. doi: 10.1073/pnas.1817342115.
Kiaris H., Support for Living Stock Collections: A Mammalian Stock Center Perspective. Trends Genet. 2018 Dec 23. pii: S0168-9525(18)30207-5. doi: 10.1016/j.tig.2018.12.001
Farmaki E., Kaza, V., Chatzistamou I., Kiaris H., CCL8 promotes postpartum breast cancer by recruiting M2 macrophages. iScience 2020 Jun 1;23(6):101217. doi: 10.1016/j.isci.2020.101217.
Naderi A., Soltanmaohammadi E., Kaza V., Barlow S., Chatzistamou I., Kiaris H., Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus. Elife. 2021 May 7;10:e64711. doi: 10.7554/eLife.64711. PMID: 33960931.
Zhang Y., Chatzistamou I., Kiaris H., Transcriptomic coordination at hepatic steatosis indicates robust immune cell engagement prior to inflammation. BMC Genomics 22, 454 (2021). https://doi.org/10.1186/s12864-021-07784-y
Horvath S., Haghani A., Zoller J.A., Naderi A., Soltanmohammadi E., Farmaki E., Kaza V, Chatzistamou I., Kiaris H., Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy. GeroScience 2021. https://doi.org/10.1007/s11357-021-00472-5
Kiaris H., Nontraditional models as research tools: The road not taken. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2024.07.005. 2024.
Kiaris H., Biology as a construct: Universals, historicity, and the postmodern nature of biological sciences. Perspectives in Biology and Medicine. 67 (3):337-347, 2024.
Books
Hippokratis, Kiaris. Understanding carcinogenesis: An Introduction to the molecular basis of cancer. Wiley-VCH, 178 pages, May 2006.
Hippokratis, Kiaris. Genes, Polymorphisms, and the Making of Societies: A Genetic Perspective of the Divergence between East and West. (Revised and Extended edition). Universal Publishers. 216 pages. 2021.
Hippokratis, Kiaris. The End of the Western Civilization? The Intellectual Journey of Humanity to Adulthood. Vernon Press, Delaware USA 118 p. 2023.