Education

Ph.D.  Biostatistics, University of South Carolina, 2013

Background

Chao Cai, Ph.D. is an assistant professor in the Department of Clinical Pharmacy and Outcomes Sciences at the University of South Carolina College of Pharmacy in Columbia, South Carolina.

Dr. Cai received her masters degree in Applied Statistics from University of Pittsburgh in 2003 and Ph.D. in Biostatistics from the University of South Carolina in 2013. Her areas of expertise include applying advanced statistical methods in outcomes sciences and providing statistical consulting in collaborative research.

Research Interests

• Survival Analysis
• Mediation Analysis
• Predictive Models
• Medication Adherence and Persistence Analysis
• Statistical Design and Analysis in Health Outcomes Sciences

Publications

Cai C, Strickland K, Knudsen S, Tucker SB, Chidrala CS, Modugno F. Alzheimer Disease and Related Dementia Following Hormone-Modulating Therapy in Patients With Breast Cancer. JAMA Netw Open. 2024 Jul 1;7(7):e2422493.  PMID: 39012631; PMCID: PMC11252894

Cai C, Kozma C, Patel C, Benson C, Yunusa I, Zhao P, Reeder G, Narasimhan M, Bank RL. Adherence, health care utilization, and costs between long-acting injectable and oral antipsychotic medications in South Carolina Medicaid beneficiaries with schizophrenia. J Manag Care Spec Pharm. 2024 Jun;30(6):549-559.  PMID: 38824623; PMCID: PMC11144998

Cai C, Knudsen S, Weant K. Opioid Prescribing by Emergency Physicians: Trends Study of Medicare Part D Prescriber Data 2013-2019. J Emerg Med. 2024 Mar;66(3):e313-e322. PMID: 38290881

Williams A, Webster WZ, Cai C, Milgrom A, Al-Hasan M, Bookstaver PB. Evaluation of the diagnostic utility of metagenomic next-generation sequencing testing for pathogen identification in infected hosts: a retrospective cohort study. Ther Adv Infect Dis. 2024 PMID: 38404751; PubMed Central PMCID: PMC10893884

Naderi A, Farmaki E, Chavez B, Cai C, Kaza V, Zhang Y, Soltanmohammadi E, Daneshvar N, Chatzistamou I, Kiaris H. Beneficial effects of CCL8 inhibition at lipopolysaccharide-induced lung injury. iScience. 2022 Dec 22;25(12):105520. PMID: 36404927; PMCID: PMC9639378

Cai C, Love BL, Yunusa I, Reeder CE. Applying mixture cure survival modeling to medication persistence analysis. Pharmacoepidemiology and Drug Safety. 2022;1‐8. doi:10.1002/pds.5441. PubMed PMID: 35426193 .

Cai C, Yunusa I, Tarhini A. Estimated Cost-effectiveness of Atezolizumab Plus Cobimetinib and Vemurafenib for Treatment of BRAF V600 Variation Metastatic Melanoma. JAMA Netw Open. 2021 Nov 1;4(11):e2132262. doi: 10.1001/jamanetworkopen.2021.32262. PubMed PMID: 34762112; PubMed Central PMCID: PMC8586909.

Yunusa I, Love BL, Cai C, Hastings T, Reeder CE, Blake EW, Phillips C. Trends in Insulin Prescribing for Patients With Diabetes During the COVID-19 Pandemic in the US. JAMA Netw Open. 2021 Nov 1;4(11):e2132607. doi: 10.1001/jamanetworkopen.2021.32607. PubMed PMID: 34730822; PubMed Central PMCID: PMC8567113.

Prinz RJ, Metzler CW, Sanders MR, Rusby JC, Cai C. Online-delivered parenting intervention for young children with disruptive behavior problems: a noninferiority trial focused on child and parent outcomes. J Child Psychol Psychiatry. 2021 Apr 8;. doi: 10.1111/jcpp.13426. PubMed PMID: 33829499.

Shealy K, Phillips C, Bzowyckyj A, Gupta V, Guyton J, Westberg S, Cai C, Trujillo J, Goldman J. Endocrine pharmacotherapy education in United States colleges and schools of pharmacy. J Am Coll Clin Pharm. 2021; 4: 481– 489. https://doi.org/10.1002/jac5.1393

Wang Y, Zhang J, Cai C, Lu W, Tang Y. Semiparametric estimation for proportional hazards mixture cure model allowing non-curable competing risk. Journal of Statistical Planning and Inference. 2020 June.

Fairchild A, Cai C, McDaniel H, Shi D, Gottschall A, Masyn K, Evaluating A method to Estimate Mediation Effects with Discrete-Time Survival Outcomes. Frontiers in Psychology, Quantitative Psychology and Measurement, 05 April, 2019 https://doi.org/10.3389/fpsyg.2019.00740

Cai C, Wang S, Lu W, Zhang J, NPHMC: An R-Package for estimating sample size of proportional hazards mixture cure models, Computer Methods and Programs in Biomedicine, 113: 290-300, 2014

Cai C, Zou Y, Peng Y, Zhang J, smcure: An R-Package for estimating semiparametric mixture cure models, Computer Methods and Programs in Biomedicine, 108:1255–1260, 2012

Tarhini A, Kirkwood M, Gooding W, Cai C, Agarwala S. Durable Complete Responses With High-Dose Bolus Interleukin-2 in Patients With Metastatic Melanoma Who Have Experienced Progression After Biochemotherapy. Journal of Clinical Oncology, 25, 3802-3807, 2007

Akhavan A, Keith D, Bastacky I, Cai C, Wang Y, Nelson B. The proportion of cores with high-grade prostatic intraepithelial neoplasia on extended-pattern needle biopsy is significantly associated with prostate cancer on site-directed repeat biopsy. BJU International, 99, 765-769, 2007

Patel H, Stoller R, Auber M, Potter D, Cai C, Zamboni W, Kiefer G, Matin K, Schmotzer A, Ramanathan R. Phase II Study of Rubitecan an Oral Camptothecin in Patients with Advanced Colorectal Cancer Who Have Failed Previous 5-Fluorouracil based Chemotherapy. Investigational New Drugs, 24, 359-363, 2006

Gologan A, Bastacky S, McHale T, Yu J, Cai C, Monzon F, Dhir R. Age-associated changes in Alpha-methyl CoA racemase (AMACR) expression in non-neoplastic prostatic tissues. American Journal of Surgical Pathology, 29, 1435-1441, 2005

Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, Cummings S, Stone KL, Morin PA, Greene D, Cauley JA. The Association of Estrogen Receptor Alpha Polymorphisms with Breast Cancer. Risk in Older White Women. International Journal of Cancer, 116, 984-991, 2005

Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, Cummings S, Stone KL, Morin PA, Greene D Cauley JA. Estrogen Metabolizing Polymorphisms and Breast Cancer Risk among Older White Women. Breast Cancer Research and Treatment, 93, 261-70, 2005

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